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LDH profiles of male and female rats treated with Vepacide

Identifieur interne : 002208 ( Main/Exploration ); précédent : 002207; suivant : 002209

LDH profiles of male and female rats treated with Vepacide

Auteurs : M. F. Rahman [Inde] ; M. K. J. Siddiqui [Inde] ; Kaiser Jamil [Inde]

Source :

Phytotherapy Research [ 0951-418X ] ; 2002-03.

RBID : ISTEX:BF6CB48F7136DCBC597F940AFC6C8140E479CACF

English descriptors

Teeft :
- Active ingredient, Azadirachta indica, Biochemical, Biochemical parameters, Biochemical target enzyme lactate dehydrogenase, Biochemical toxicology, Biology division, Bull environ contam toxicol, Chemical technology, Correlation studies, Days post treatment, Different tissues, Dimorphism, Dos, Enzyme, Female albino wistar rats, Female rats, High degree, High dose, High doses, Indian institute, John wiley sons, Kidney tissues, Lung tissue, Lung tissues, Male rats, Medium dose, Methyl parathion, Neem, Neem seed kernel, Negative correlation, Oral administration, Percentage increase, Polychlorinated biphenyl, Positive correlation, Present investigation, Present study, Rahman, Rat, Rats period control, Relative changes, Sexual dimorphism, Tissue damage, Tissue injury, Tissue necrosis, Vepacide, Withdrawal study.

Abstract

In the present study we investigated the effect of vepacide, a neem‐based compound, on the biochemical target enzyme lactate dehydrogenase (LDH) in different tissues of male and female albino Wistar rats treated orally with 80, 160 and 320 mg/kg (low, medium and high doses, respectively) for a period of 90 days. Prolonged administration of vepacide caused a significant increase of LDH activity in serum and lung tissues and a decrease in liver and kidney in both male and female rats when measured after 45 and 90 days of daily treatment. Females were more susceptible than males with regard to serum and kidney LDH showing sexual dimorphism in the treated rats. Recovery was observed in the affected enzyme after 28 days post treatment (withdrawal study). A positive correlation was observed with regard to this enzyme between serum and lung tissues, whereas for serum versus liver and kidney there was a negative correlation. The effect of vepacide was more pronounced in the lung tissue followed by liver and kidney tissues. Necrosis of the liver and kidney tissues was observed but in the lung tissue an increase in the LDH enzyme was seen. Therefore, it was concluded that the increase in LDH could be indicative of a stress adaptive response to the toxicant. Copyright © 2002 John Wiley & Sons, Ltd.

Url:

https://api.istex.fr/ark:/67375/WNG-8LRCFK19-M/fulltext.pdf

DOI: 10.1002/ptr.809

Affiliations:

Inde

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Le document en format XML

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<term>Biochemical toxicology</term>
<term>Biology division</term>
<term>Bull environ contam toxicol</term>
<term>Chemical technology</term>
<term>Correlation studies</term>
<term>Days post treatment</term>
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<term>Medium dose</term>
<term>Methyl parathion</term>
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<term>Sexual dimorphism</term>
<term>Tissue damage</term>
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<term>Vepacide</term>
<term>Withdrawal study</term>
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<front><div type="abstract" xml:lang="en">In the present study we investigated the effect of vepacide, a neem‐based compound, on the biochemical target enzyme lactate dehydrogenase (LDH) in different tissues of male and female albino Wistar rats treated orally with 80, 160 and 320 mg/kg (low, medium and high doses, respectively) for a period of 90 days. Prolonged administration of vepacide caused a significant increase of LDH activity in serum and lung tissues and a decrease in liver and kidney in both male and female rats when measured after 45 and 90 days of daily treatment. Females were more susceptible than males with regard to serum and kidney LDH showing sexual dimorphism in the treated rats. Recovery was observed in the affected enzyme after 28 days post treatment (withdrawal study). A positive correlation was observed with regard to this enzyme between serum and lung tissues, whereas for serum versus liver and kidney there was a negative correlation. The effect of vepacide was more pronounced in the lung tissue followed by liver and kidney tissues. Necrosis of the liver and kidney tissues was observed but in the lung tissue an increase in the LDH enzyme was seen. Therefore, it was concluded that the increase in LDH could be indicative of a stress adaptive response to the toxicant. Copyright © 2002 John Wiley & Sons, Ltd.</div>
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LDH profiles of male and female rats treated with Vepacide

LDH profiles of male and female rats treated with Vepacide

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English descriptors

Abstract

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